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Breakthrough Announcement: Enteromix Ready for Clinical Use
At the 10th Eastern Economic Forum held in Vladivostok (September 3–6, 2025), Veronika Skvortsova, head of Russia’s Federal Medical and Biological Agency (FMBA), announced that the Enteromix vaccine has completed the mandatory preclinical trials and is now “ready for clinical use”, pending formal approval from the Ministry of Health India TodayThe Economic Times@mathrubhumiNewswire.
mRNA-Powered Therapy: How Enteromix Works
Enteromix is an mRNA-based cancer vaccine, employing the same foundational technology as COVID-19 vaccines. It’s designed to train the immune system to recognize and eliminate cancerous cells India TodayOpIndiaNewswire. The approach allows personalization, tailoring the vaccine to a patient’s unique tumor RNA profile, often leveraging AI to target cancer-specific neoantigens OpIndiaThe Economic Times.
Preclinical Trial Highlights
Efficacy and Safety
Across preclinical trials, Enteromix demonstrated remarkable reduction in tumor size—between 60% to 80%, varying by cancer type India TodayThe Economic Times@mathrubhumiBusiness StandardBusiness Today.
Some sources even report 100% efficacy, suggesting either complete tumor elimination or highly potent therapeutic response Business TodayThe Economic Times+1The Times of India.
Trials also confirmed strong safety, with no serious adverse effects observed—even after repeated doses India TodayOpIndiaNewswireThe Economic Times.
Improvements in survival rates were noted among test subjects India TodayThe Economic TimesBusiness Standard.
Efficacy and Safety
Across preclinical trials, Enteromix demonstrated remarkable reduction in tumor size—between 60% to 80%, varying by cancer type India TodayThe Economic Times@mathrubhumiBusiness StandardBusiness Today.
Some sources even report 100% efficacy, suggesting either complete tumor elimination or highly potent therapeutic response Business TodayThe Economic Times+1The Times of India.
Trials also confirmed strong safety, with no serious adverse effects observed—even after repeated doses India TodayOpIndiaNewswireThe Economic Times.
Improvements in survival rates were noted among test subjects India TodayThe Economic TimesBusiness Standard.
Vaccine Targets and Next Steps
Initial Target
Enteromix will first focus on colorectal cancer (colon cancer) India TodayThe Economic Times@mathrubhumiNewswireBusiness Standard.
Further Development
Researchers are advancing versions targeting glioblastoma (an aggressive brain cancer) and certain forms of melanoma, including ocular melanoma (a rare eye cancer) India TodayThe Economic Times@mathrubhumiBusiness Standard.
Regulatory Pathway
With preclinical success, Enteromix is now awaiting official approval from Russia’s Ministry of Health. Reports indicate Phase I clinical trials will begin imminently, potentially involving around 48 human volunteers Business TodayOpIndia.
Significance and Global Implications
If Enteromix gains approval for human use, it could mark a historic milestone in cancer treatment—the first personalized mRNA cancer vaccine available clinically. Its success may herald a shift from conventional treatments like chemotherapy toward highly targeted, immune-based therapies Business TodayThe Economic TimesThe Times of India.
Its deployment could pave the way for personalized oncology on a global scale, offering new hope in areas where existing treatments are limited, such as glioblastoma or rare melanomas.
If Enteromix gains approval for human use, it could mark a historic milestone in cancer treatment—the first personalized mRNA cancer vaccine available clinically. Its success may herald a shift from conventional treatments like chemotherapy toward highly targeted, immune-based therapies Business TodayThe Economic TimesThe Times of India.
Its deployment could pave the way for personalized oncology on a global scale, offering new hope in areas where existing treatments are limited, such as glioblastoma or rare melanomas.
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